Parkinson’s disease Disease

About Gene:

Parkinson's disease is a brain disorder in which part of the brain becomes progressively damaged over many years.

Number of Patients: 0

Disease Causing Genes:

MT-ND2 MEF2D BAG2 FRAXE CHGB ITGA7 ADH5 RTN3 CNTN1 ELAVL4 SNCB FAF1 CNKSR3 GLUD2 EN2 VPS26A SNHG14 SOX2-OT MIR425 RHOT1 PIK3R3 NDUFV2 HOXA11-AS PARK16 SNHG7 MAPT-AS1 SNCA MAPT LRRK2 GBA1 GAK LINC00693 BST1 HLA-DRA NSF APOE CRHR1 MCCC1 NUCKS1 RIT2 WNT3 TNF MTHFR HLA-DQB1 TP53 APP BDNF VDR SCARB2 COMT IL6 GCH1 EGFR NFE2L2 DGKQ SLC6A4 VEGFA AKT1 ABCB1 SREBF1 CYP17A1 STK39 CRP DRD2 IL10 SIRT1 IGF1 ACE BMP4 DLG2 PTGS2 GSTM1 HLA-DRB1 IL1B LAMP3 TMEM175 ERBB2 HIF1A SOD1 ESR1 TLR4 SLC6A3 NFKB1 PON1 PRKN NLRP3 BRAF MMP9 ADIPOQ GSK3B CXCL8 CTNNB1 PTEN CDKN2A PPARGC1A IFNG PARP1 TARDBP PPARG GSTT1 CXCR4 MTOR GSTP1 CCL2 BCL2 HMOX1 HFE TLR2 CYP2D6 XRCC1 GPNMB SERPINE1 MMP2 SYT11 IL17A PARK7 CD4 C9orf72 PINK1 SLC41A1 CCR5 APOA1 HMGB1 EZH2 ESR2 ADRB2 LMNB1 F2 SOD2 RET SPP1 S100B ADORA2A IL18 GHRL ALDH2 TREM2 FAS UCHL1 SP1 RAC1 AGER DRD3 LGALS3 CFH MAOA FMR1 NOD2 FAM47E CASP3 INS CNR1 NAT2 CYP1A1 ABL1 HBB FGF20 CLU SERPINA1 MIR155 GRN MALAT1 DRD4 HSPA5 EP300 CCDC62 PCSK9 CD14 TH CCL5 TTR IGF2 NOS2 IL1A HTT TLR9 CST3 ALB OGG1 C3 NQO1 HTR2A E2F1 MIR34A MPO MCL1 GDF15 EIF4G1 TLR3 TNFRSF1A APEX1 SQSTM1 CHI3L1 POLG DNMT1 HP TRPV1 DBH FRAXA HLA-DQA1 HSPA8 NR4A2 XIAP MAOB BCL2L1 CYP2E1 PCNA P2RX7 PTX3 NRG1 SHH IDO1 HSPA4 HOTAIR NEAT1 CREB1 CD36 TF BECN1 CYP1A2 ALDH1A1 FUS PRKCD TGM2 VCP ACMSD DNMT3A NOTCH3 VCAM1 TRAF6 SIRT3 MIR29A DNMT3B NFKBIA NOS1 GH1 PLA2G6 FGF21 PRKAA1 GDNF UCP2 IL6R NTRK2 CCR2 AQP4 FAM47E-STBD1 FYN PAX6 ADAM17 BCL2L11 CP MIR126 XRCC3 SH3GL2 FKBP5 NCAM1 SLC2A13 TSC2 CTSD TET2 CACNA1C CEBPB RAB25 USP25 MIR221 HTR1A FGB CTSB TFRC ANG YWHAZ VPS13C DNM1L GFAP ANXA1 HTRA2 FGA EIF2AK2 VPS35 CLOCK CYBB NEFL DRD1 ADH1B AQP1 RAI1 GCG ATP13A2 CDK5 CHRNA7 TBP STUB1 IL27 L1CAM GRIN2B GPX1 MIR223 LAMP2 CASP9 NGFR CD163 GAPDH BCHE MTR GLA MFN2 EPHX1 ATXN2 ADAM10 AGO2 CHGA GLP1R MEG3 SLC18A2 MIR17 FGG CNR2 SPHK1 SMPD1 CTC1 ATF4 TFAM SIRT6 SIRT2 WWOX MIR205 NR4A1 DAPK1 MTRR HSPA9 ATXN3 CR1 PPP2CA MIR195 WFDC2 VDAC1 MIR214 SLC19A1 SKP1 PEBP1 MIR150 TNFSF12 HIP1R CTSL MIR137 SORL1 FADD TRIM28 CFL1 XIST ACHE SLC1A2 TRPM7 MIR124-1 SNAP25 ATG5 SLC6A2 PHB1 TSPO TUG1 MIR141 MIR29B1 MAP3K5 TAP1 DYRK1A CCL3 HDAC4 CHRNA5 NPC1 MIR22 GIGYF2 HMGCR CRH CYP27B1 REST ATG16L1 CAPN1 TPM1 MMRN1 PRDX2 SLC11A1 PSAP SRY FTL LIN28A ITGA8 PSEN2 SNHG12 TRPM8 ARSA HTR1B CHCHD2 GRIN2A SLC11A2 CHRNA4 PON2 MIR132 SLC2A9 MIR144 ADH1C IL16 NTN1 CNNM2 SNCAIP AXIN1 FBXO7 MIR26A1 LAG3 BMAL1 RTN4 DLG1 STX1B SLC22A5 UNC13B NR0B1 RAB7A CHRNA3 TRPM2 TOMM40 APAF1 BIN1 FTH1 PITX3 TCIM MEF2C CIP2A SLC7A11 AKT3 CHIT1 SRF TAP2 ADORA1 HCRT KNG1 FABP3 MT-ND1 DLG4 HLA-DRB5 GDF5 GAD1 TAS2R38 DDRGK1 PTGES CD200 ANKK1 CCK MIR133B PAWR VIP REL PICALM UGT1A9 BCKDK HAX1 MIR29C SLC45A3 TNFRSF9 NEDD8 PAK4 DDC TRIB3 NEDD9 DHCR7 KLK6 STX1A PDHA1 CD33 NR1H2 IFNL1 KCNA3 MIR34C EPHX2 NR4A3 DCC SIAH1 MIR106A MIR17HG CAST PBX1 TCN2 GAD2 CCKBR MIR7-1 MIR146B MIR494 MIR138-1 PRDX3 SESN2 MIR24-1 TMEM163 MIR193A S100A10 MIR152 SLC1A1 GRM5 OPRK1 BACH1 MIR124-3 CHRM1 LBP APCS SST NPPC TOP2B ATG7 IL1R2 STAP1 PSMB8 HRH4 MIR34B TMEM230 GRK5 NR2F2 ASCL1 SLC8A1 PDYN LONP1 CALB2 TFR2 MIR15B ISM1 SIPA1L2 NQO2 PER1 PMEL CYP2R1 MT-ATP6 SDHA GSTO1 OTX2 SYNJ1 TLR10 WASL NTSR1 UBQLN1 LINGO1 RFC1 CASK MIR19B1 DNAJB6 RAB8A NORAD NTF3 CALB1 VAMP2 INPP5F MIR135B HNMT DRD5 GPBAR1 NDUFA13 PDE4B CHRNB4 PM20D1 LRP8 PSMC4 GBF1 MIR485 GLRX TNK2 LINC02210 PTPRA GALC ABCA7 PRDX5 LMX1B PDE4A TNFAIP8L2 PSMB9 COL6A3 CCKAR SNAP23 PRDM15 SUMO3 STBD1 SPPL2B AFDN TRIM27 MIR134 NFIB NR2F1 SYT4 MIR135A1 MT-ND4 SFXN2 HMOX2 SUMO4 CDK5R1 TMEM106B TOX3 RAB29 PSMC1 MAP1B WASF2 PLK2 MIR301A NRGN CHMP2B DNAJC13 HTR6 CHCHD10 RAB10 BORCS7 NUS1 ADNP MANF GSTO2 MACF1 MIR24-2 CD200R1 PSMB4 MIR29B2 GRIN2C SEPTIN4 PPP2R5D PROK2 HACE1 MT-ND3 GRK6 SPPL2C MIR153-1 ENDOG TPPP DNM3 BNIP3L TOR2A ATG12 TOMM20 TP53INP1 LRP10 SRRM2 TRIP12 MMP16 SPR P2RY6 PARL RNF41 DNAJC6 IL13RA1 SEMA5A C19orf12 PARK10 SCG2 UQCRC1 QDPR DUSP22 RPS15 LRRC32 LMX1A ODAPH MIR1-2 COQ2 TRIM11 RAB35 STMN2 STX6 KCNJ3 CHRNB3 MIR433 PACRG FTMT HLA-DQA2 TNR NPTX2 RAB39B CNTN2 GSTA4 EN1 PAK6 TRIM3 RAP1GDS1 NUCB1 SLC18A3 STH GPR37 NDUFV1 BAG5 ZNF646 CLRN3 ASIC2 NUB1 RIC3 ATXN8OS NSFL1C TRDN LRRK1 NCAPD2 LY6E RGMA LINC-PINT GBAP1 SLC50A1 MIR7-2 MIR942 PRSS53 MIR384 VPS29 TMEM229B CDNF PLXNA1 SYNPO NDFIP1 MUL1 INPP5K MIR7-3 YKT6 MTIF3 CDR2 ITPKB SYN3 MIR302B MIR505 MIR376A1 RNF11 TGM6 PDE7A MIR1301 NOTCH2NLC PGLYRP2 VPS41 DNAJC12 SLC25A46 LPO NRXN2 NDUFA1 SLC17A8 ZNF512B OBP2A PPHLN1 VAMP4 KCNJ15 MIR4697 SLC30A3 BACE1-AS MIR153-2 RASD2 SIPA1L1 PLXNA4 MOBP MKRN2 HSP90AB2P TEF RNF19A NADSYN1 SIDT2 MBNL2 ZNF746 COQ7 NDUFB8 TRIM41 PAQR7 FGF11 AMIGO2 CADPS2 CYP17A1-AS1 LOC100287944 LOC102723370 POU3F3 LINGO2 TRIM17 MS4A6A NMD3 RMST CHP2 PTRHD1 ATXN8 KCNS3 NAIF1 MIR520D PHACTR2 MIDN SAMD4A IRX2 MTFP1 ZNF184 ATP10B ZSCAN21 SEPTIN14 SLC25A44 PGLYRP4 SYNGR3 SELENOT FBRSL1 LHFPL2 ZNF543 MIR626 PARK3 KDM7A-DT PARK12 MIR5701-1

Sign and Symptoms:

  1. Tremor
  2. Slowness of movement
  3. Voice disorders
  4. Sensory and sleep difficulties
  5. Insomnia
  6. Excessive sweating
  7. Bradykinesia
  8. Muscular Rigidity
  9. Mask- like face expression
  10. Postural instability
  11. Festination
  12. Respiratory dysfunction
  13. Autonomic dysfunction
  14. Orthostatic hypotension
  15. Day time drowsiness

Diagnosis:

(1) Medical history collection (2) Physical examination

Preventions:

Treatment:

There is no cure for Parkinson's disease, there are several measures that can be taken to improve a patient's quality of life.