BGDD

13

female

dhaka

interleukin and interleukin receptor gene polymorphisms

IL-23R mutation

Diarrhea, often with blood or pus Rectal bleeding — passing small amount of blood with stool Abdominal pain and cramping Rectal pain Urgency to defecate Inability to defecate despite urgency Weight loss Fatigue Fever In children, failure to grow

Hb-9.6 g/dl, white cell count 8.4/cu mm with neutrophilia (74%) and thrombocytosis (615/cu mm). ESR was 69 mm in 1st hr, CRP was high (4.08 mg/dl), mild hypokalaemia (3.1) in S.electrolytes

Anti-inflammatory medications Anti-inflammatory medications are often the first step in the treatment of ulcerative colitis and are appropriate for most people with this condition. These include: 5-aminosalicylates. Examples of this type of medication include sulfasalazine (Azulfidine), mesalamine (Delzicol, Rowasa, others), balsalazide (Colazal) and olsalazine (Dipentum). Which medication you take and how you take it — by mouth or as an enema or suppository — depends on the area of your colon that's affected. Corticosteroids. These medications, which include prednisone and budesonide, are generally reserved for moderate to severe ulcerative colitis that doesn't respond to other treatments. Corticosteroids suppress the immune system. Due to the side effects, they are not usually given long term. Immune system suppressor Immunosuppressant medications include: Azathioprine (Azasan, Imuran) and mercaptopurine (Purinethol, Purixan). Cyclosporine (Gengraf, Neoral, Sandimmune). This medication is typically reserved for people who haven't responded well to other medications. Cyclosporine has the potential for serious side effects and is not for long-term use

colonoscopy and histopathology our patient was labeled as a case of severe UC and was treated accordingly. At a follow up visit 2 weeks later she reported that her diarrhea had improved. There was no visible blood in the stool. She had no fever or abdominal pain