Ulcerative colitis Disease

About Gene:

The colon and rectum become inflamed when someone has ulcerative colitis, which is a chronic illness. The big intestine (colon) is the rectum, which is the end of the gut where waste is kept. On the lining of the colon, small ulcers can form and bleed or create pus.

Number of Patients: 1

Disease Causing Genes:

DEFA1A3 NEWENTRY TNF ORMDL3 DLD SLC6A4 IL10 IL26 PPARG PTGS2 BRAF GPR35 IFNG-AS1 HLA-DRB1 HLA-DQB1 IL21 GSDMB IFNG IL2 CRP RNF186 ADIPOQ DDR1 CD14 JAK2 IL6 OTUD3 NFKB1 TCF4 BCL2 MMP1 AGER MLH1 FCGR2A IL22 APOE NOD2 NLRP3 FOXP3 LGALS3 HMGB1 SATB2 IL23R VDR VEGFA CDKN2A IL37 LEP IL18 TNFRSF6B HLA-G HLA-DQA1 ABCB1 EGFR KRAS INAVA BIRC5 XRCC1 SOD1 IL4 HLA-E IL1B CXCL8 ESR1 MIR21 S100A9 SIRT1 SPP1 NR3C1 RB1 TNFSF15 HLA-DRB5 BSN IL7R IGF1 ICAM1 MST1R CXCR1 SOD2 HLA-DRA TLR4 IL17A AKT1 GSTM1 CIITA MIF CD44 MIR146A LCN2 BTNL2 STAT3 SLC26A3 ACE HLA-B RELA PTGER4 IL33 HMOX1 LAMB1 TGFB1 MTHFR CXCR2 NFE2L2 CD4 REL GSTP1 CYP2D6 FAS CARD9 MMP9 CTLA4 CTNNB1 TLR2 NKX2-3 CFB MET MIR155 HDAC9 TP53 HNF4A PLA2G2E IRF5 GSTT1 FCGR2B PIK3CA MST1 IL12B PARK7 PTEN CXCR4 CCL2 PON1 NOTCH4 IL1RN TNFRSF9 MICA MBL2 APOA1 APC PTPN22 MMP3 TNFSF10 ITGB1 MUC1 IRF8 CDH1 IL19 GPX1 PTPRC CCND1 SLC11A1 IL1R2 SMURF1 STAT1 UTS2 TIMP1 RAC1 CYP1A1 HLA-C NOS2 F3 CYP3A4 HSPA1L NKX3-1 PTPN11 TNFRSF14 RUNX3 FLOT1 TNFRSF11B NAT2 CXCL10 PCSK9 SMAD4 KIF21B TCF7L2 LINC01475 CYP3A5 SOCS3 LEPR SMAD3 TLR9 TWIST1 LPL AURKA MIR34A IL13 MPO MCL1 IGF2 CALCA IGFBP3 MEFV TNFRSF1A APEX1 IL6R CHI3L1 MALAT1 NAMPT HSPA4 DNMT1 NQO1 LGALS1 FASLG MIR145 BCL2L1 PUS10 GRN PTX3 HSPA6 IDO1 CD40LG TNPO3 RTEL1 CD40 PPARA CALR GNA12 MMP14 S100B IL2RA GATA3 FCGR3A ANXA2 LTF ELAVL1 IER3 SOCS1 IKZF3 NR1I2 MMP7 TNFRSF1B EGR1 TGFBR1 HAVCR2 F2RL1 IL27 CDX2 SMAD2 HPSE ICOSLG USP4 H2AX ADAM17 NEAT1 F2R ADORA2A CD209 ACTR3B IL23A FKBP5 SELE SERPINF1 ALDH1A1 SPARC S100A8 MUC16 SMAD7 IL1RL1 ZFP90 AHSG CAT CACNA2D1 FHIT TPMT TPPP MIR29A MME CBS CHGA RXRA LSP1 PNMT PIM3 ATG16L1 MIR195 GCG MIR221 PTPN6 IL12A PFKFB4 SEC16A MIR223 CASP9 TRAF2 MIR143 TSLP CDKN2B-AS1 CD163 CFLAR ZAP70 CYBA MTR EPHX1 CD38 ADAM10 CD24 STAT6 ELANE STAT5A TNC MEG3 CX3CR1 PECAM1 NCOA3 NR1H4 MYB HTRA1 CXCR3 GTF2H4 IL7 STAT4 CLDN1 XBP1 HSD11B1 RARRES2 DEFB4A MUC2 KRT18 APOH IL9 SFTPD TREM1 CRHR1 AICDA MIR31 DEFB1 MIR125A PTPN2 CNR2 TNFRSF8 TFPI ERN1 COL13A1 MIR142 SLC9A1 NR4A1 CCL3 PTGS1 GPD2 DAPK1 MIR196A2 CYP24A1 APEH CD55 MSH5 TLR5 TJP1 TXNIP MMP8 CCHCR1 CXCL13 FABP2 MIR124-1 NOD1 MIR222 TNFSF8 IL17F CA2 PROCR SLC22A5 MIR182 BIRC3 CCNY TUG1 TNFSF12 ISG15 CD86 SLC7A5 TACR1 MIR200B CHRNA5 SFRP1 MIR499A MIR16-1 MDK ENPP2 IL17REL TERF2 IL11 MIR148A SLC16A1 NFATC1 S1PR1 HSD11B2 PADI4 MICB IL5 EIF2S1 CD80 SELL IL10RA UCN2 TAC1 INPP5E LINC00243 PRSS1 APOA4 KLF6 TBX21 FUT2 CCL11 OCLN FCGR3B CCL21 EIF2AK3 SCD FCGR2C ADH1C CEP72 KRT8 TFF3 TYK2 PRDM1 EXOC3 KCNN4 KHDRBS1 HSPA1B C1QBP ATF6 ITGAL CCR6 VASP VIP SERPINA12 MTHFD1 AKR1C3 PER3 CXCL5 GMPPB S100A12 SLIT2 AGR2 IFITM3 CLDN4 ICOS USP12 UBA7 DUOX2 FOSL1 SLC22A4 MIR19A VARS2 PANX1 FPR1 AAMP CCR3 GPR55 SLC44A4 IP6K1 MFGE8 TCN2 CYP2J2 SCNN1B MIR24-1 HLA-DRB3 IP6K2 KRT1 PTGDS ID2 CYCS RAB27A SERPINH1 KRT7 CTSG KCNA3 ADAM9 EPHX2 DCC TRAP1 ECM1 ST14 MIR106A CBX3 MIR224 CLEC7A PLIN2 MIR193A CEACAM6 ARHGDIA CLDN2 INPP5D MMEL1 FUT3 BCL3 ATG7 PI3 TNFRSF12A ENTR1 VIPR1 CCL26 LRG1 CXCL11 PIGR IRGM MMP10 TNIP1 GATD3 CLDN7 ZGPAT BCL2L12 REG1A CARD8 SDHA IL13RA2 MSH3 S100A1 F2RL3 KRT20 FUT8 STMN3 SCNN1G SLC9A3 NORAD NTF3 CD1A IFITM1 GPBAR1 AKAP12 INSL4 ELF3 CRHR2 CD83 MT-ND4 MYO9B DEFA5 KPNA7 DAP SNAPC4 HMGB2 MIR590 ZBTB46 EED MGAT5 CIRBP MIR506 HSF2 TOLLIP PTGDR2 DLG5 HERC2 TRIM22 TERF2IP IL20 PLCH2 ZPBP2 AQP8 CCR9 BPI P2RX3 ALDOB SLC2A4RG ITGAE EYA4 NCF4 EBI3 GUCY2C TMEFF2 ALPI CITED2 IL10RB HCRTR1 MRGPRX2 PON3 HNMT HCG9 ADAD1 SERINC3 CALHM6 FLII CPXM2 TRAF3IP2 CCL24 IRAK3 TIMD4 TIMP4 OGA MACF1 MIR24-2 PTPRO AQP7 LGALS4 CLDN18 PHLPP2 SERPINB1 LGALS2 TUBB6 NUCKS1 UTS2R ADAM19 NEK6 MADCAM1 ARPC2 MIR433 PTPRS MARVELD2 CCL25 IL17RD GP2 RAB13 CCL28 CYC1 SLC18A3 INSL6 ZBTB7B APBA1 RGS16 MFSD2A SMOX MIR588 NCAPD2 GUCA2B SLC6A14 GPR65 SLC15A4 LACC1 AMIGO3 ACSM3 PLEK LINC00598 CLEC2D IL17C RC3H1 MUC20 RTEL1-TNFRSF6B GZMM GUCA2A CYP4F3 SCGN GDE1 ATG10 MAFK PITX1-AS1 NCAPD3 CIDEB LSAMP BRINP3 PANX2 OVGP1 INSL5 HCG26 DNAJC15 IBD5 DUOXA2 LRCH1 ACAT2 RNF128 AGPAT1 CD300LF ST6GALNAC1 LEFTY1 KCNN1 CPA6 BMP8B NXPE1 MROH3P LOC100996583 UQCRQ MUC12 MIR598 ZNF133 RAVER2 MIR4728 MIR642A ZNF649 PROSER1 MIR4284 MIR2053 EXOC3-AS1

Sign and Symptoms:

  1. Diarrhea, often with blood or pus. Rectal bleeding — passing small amount of blood with stool. Abdominal pain and cramping. Rectal pain. Urgency to defecate. Inability to defecate despite urgency. Weight loss. Fatigue

Diagnosis:

(1) Medical history collection (2) Physical examination (3) Stool microscopy (4) Hemoglobin test (5) Serum albumin test (6) Blood test (7) Chest X-ray (8) USG (9) Ileocolonoscopy (10) Colonic biopsy

Preventions:

Not drinking carbonated drinks. Not eating high-fiber foods such as popcorn, vegetable skins, and nuts while you have symptoms. Drinking more liquids. Eating more frequent, smaller meals. Keeping a food diary that identifies foods that cause symptoms.

Treatment:

Ulcerative colitis treatment usually involves either medication therapy or surgery. Anti-inflammatory medications (Azathioprine (Azasan, Imuran) and mercaptopurine (Purinethol, Purixan ,Cyclosporine (Gengraf, Neoral, Sandimmune).) Immune system suppressors (Infliximab (Remicade), adalimumab (Humira) and golimumab (Simponi),Vedolizumab (Entyvio),Ustekinumab (Stelara)